In September Christopher Egbulefu, PhD; Partha Karmakar, PhD; and Samuel Achilefu, PhD; published “Breast cancer derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment” The Journal of Clinical Investigation.

From the abstract: Tumor-infiltrating myeloid cells contribute to the development of the immunosuppressive tumor microenvironment. Myeloid cell expression of arginase 1 (Arg-1) promotes a protumor phenotype by inhibiting T cell function and depleting extracellular L-arginine, but the mechanism underlying this expression, especially in breast cancer, is poorly understood. In breast cancer clinical samples and in […]

In September Anchal Ghai, PhD; Samuel Achilefu, PhD; Monica Shokeen, PhD published “In vivo quantitative assessment of therapeutic response to bortezomib therapy in disseminated animal models of multiple myeloma with [ 18 F]FDG and [ 64 Cu]Cu-LLP2A PET” in EJNMMI Research.

From the abstract: Multiple myeloma (MM) is a disease of cancerous plasma cells in the bone marrow. Imaging-based timely determination of therapeutic response is critical for improving outcomes in MM patients. Very late antigen-4 (VLA4, CD49d/CD29) is overexpressed in MM cells. Here, we evaluated [18F]FDG and VLA4 targeted [64Cu]Cu-LLP2A for quantitative PET imaging in disseminated […]

In September Lindsey M Brier, PhD; Annie R Bice; Seana H Gaines; Eric C Landsness; and Joseph P Culver, PhD published “A Multivariate Functional Connectivity Approach to Mapping Brain Networks and Imputing Neural Activity in Mice” in Cerebral Cortex.

From the abstract: Temporal correlation analysis of spontaneous brain activity (e.g., Pearson “functional connectivity,” FC) has provided insights into the functional organization of the human brain. However, bivariate analysis techniques such as this are often susceptible to confounding physiological processes (e.g., sleep, Mayer-waves, breathing, motion), which makes it difficult to accurately map connectivity in health […]

Congrats to Leo Shmuylovich, MD, PhD on being awarded the NIH Director’s Early Independence Award.

This award provides support for outstanding junior scientists to bypass the traditional postdoctoral training period and launch independent research careers. With the support of the Early Independence Award, Shmuylovich aims to bring short-wave infrared macroscopic and microscopic imaging into clinical practice. Such technology has potential to address the needs of diverse populations and reduce health […]